By Frances M. Ashcroft
Ion channels are membrane proteins that act as gated pathways for the stream of ions throughout cellphone membranes. They play crucial roles within the body structure of all cells. lately, an ever-increasing variety of human and animal ailments were stumbled on to consequence from defects in ion channel functionality. each one of these illnesses come up from mutations within the genes encoding ion channel proteins, and they're now often called the channelopathies.
Ion Channels and Disease offers an informative and updated account of our current knowing of ion channels and the molecular foundation of ion channel illnesses. It features a uncomplicated advent to the appropriate features of molecular biology and biophysics and a quick description of the relevant equipment used to check channelopathies. for every channel, the connection among its molecular constitution and its practical homes is mentioned and ways that genetic mutations produce the ailment phenotype are thought of.
This ebook is meant for learn employees and clinicians, in addition to graduates and complex undergraduates. The textual content is apparent and vigorous and assumes little wisdom, but it takes the reader to frontiers of what's presently recognized approximately this most fun and medically very important quarter of body structure.
* Introduces the suitable features of molecular biology and biophysics
* Describes the crucial tools used to review channelopathies
* Considers unmarried sessions of ion channels with summaries of the physiological position, subunit composition, molecular constitution and chromosomal situation, plus the connection among channel constitution and function
* seems at these illnesses linked to faulty channel constructions and legislation, together with mutations affecting channel functionality and to what volume this alteration in channel functionality can account for the medical phenotype